# Karyopharm's Spleen Win Masks Symptom Failure in Myelofibrosis Study - Date: 2026-03-24 - Category: Biotech & Life Sciences Two biotech companies — Karyopharm and Rezolute — two very different stumbles toward the same regulator, and an FDA that may be rewriting the rulebook on what counts as enough evidence to approve a drug. Karyopharm Therapeutics on Monday reported topline results from the Phase 3 SENTRY trial of ... ---